Gut Microbiota in Human Immunodeficiency Virus Infection

Rudi Wisaksana, Guntur Darmawan, Nenny Agustanti, Dolvy Girawan


Human microbiota, majority presents in human gastrointestinal tract, plays crucial role in body physiological functions, such as immune system. Human immunodeficiency virus (HIV) infection impairs gut barrier and alter the microbiota ecosystem, called dysbiosis. Several studies showed different composition of gut microbiota between healthy individual and HIV patient. Moreover, different phase of HIV infections had their own characteristic of gut microbiota. Antiretroviral treatment might improve the CD4 level, however, it inconsistently restore the gut ecosystem. Some studies in prebiotic and probiotic revealed the potential beneficial effect in gut microbiota. Probiotic might inhibit mucosal invasion, improve intestinal mechanical barrier integrity, reduce microbial translocation, restore mucosal immune function, counteract local inflammation and lower systemic inflammation.


gut microbiota, human immunodeficiency virus; dysbiosis; probiotic

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