Life Style Factors Influencing Serum Pepsinogen Levels in Healthy Japanese: A Prospective Study
DOI:
https://doi.org/10.24871/4120036-10Abstract
Background: Gastric cancer mass screening using serum pepsinogen has been recognized and several advantages of this methods over photofluorography have been shown by previous study. Aims: To determine the factors influence the serum pepsinogen levels in healthy subjects. Subjects & Methods: One thousand and one hundred fourteen subjects who were screened for gastric cancer as part of a periodic health check. Blood samples were taken after fasting and stored below –20 ° C, until pepsinogen levels were assayed. Results: The subjects consist of 338 males (mean age 52.6+14.0) and 776 females (mean age 49.0+11.9). Age ranges from 19 to 81 years. The overall prevalence of chronic atrophic gastritis using a criterion PG I £ 70 hg/ml and PG I/II ratio £ 3.0 was 21.99 % in 1996 and 23.97 % in 2000. Bivariate analysis revealed a significant association between age, more salt consumption, fish favorable over meat and less than three time meal intake covariates with the lowering of PG I/II ratio. Smoking, drinking, BMI, weight and gender did not affect the changes of PG I/II ratio. Conclusion: Age and more salt consumption covariates have a strongest association with the decreased of PG I/II by multivariate analysis. Keywords: pepsinogen, dietary, drinking, smoking, atrophic gastritis
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2003-01-04
How to Cite
Abdullah, M., Kitahara, F., Sato, T., Kojima, Y., Rani, A. A., & Fujino, M. A. (2003). Life Style Factors Influencing Serum Pepsinogen Levels in Healthy Japanese: A Prospective Study. The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy, 4(1), 6–10. https://doi.org/10.24871/4120036-10
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