Transforming Screening, Risk Stratification, and Treatment Optimization in Chronic Liver Disease Through Data Science and translational Innovation

Tamer A. Addissouky(1),


(1) menoufia university
Corresponding Author

Abstract


Background: Chronic liver diseases continue to face challenges in prognosis, treatment selection, disease mechanisms, screening, and therapeutic optimization. Promising innovations could address these gaps through data integration and novel analytic approaches.

Main Body: MAPS-CRAFITY integrating clinical variables, AFP, and CT/MRI findings, and transformer modeling of RFA data improve HCC outcome prediction to guide management. Analyses revealing IL21R as a PBC susceptibility gene and implicating dysfunctional VWF processing in portal hypertension deliver mechanistic insights. Quantifying childhood MAFLD informs screening needs, while supporting use of G6PD deficient liver donors enables transplantation access expansion through risk stratification. Updating Baveno criteria enhances PBC prognosis, and an HCC prognostic score identifies optimal RFA candidates to maximize treatment efficacy.

Conclusion: Recent research leverages diverse data types, genetics, imaging, and machine learning to develop integrated predictive systems that allow more personalized therapy selection. Elucidating molecular pathways provides therapeutic targets and prognostic biomarkers. Evidence-based screening and risk models facilitate delivering tailored interventions. Optimization of current modalities through prognostic validation and patient selection improves real-world effectiveness. Multifaceted modern research approaches promise to address unmet needs and transform hepatology care.


Keywords


Immunogenetics; Metabolomics; Artificial intelligence; Personalized medicine; Endothelial dysfunction

References


Joo Hyun Oh; Dae Won Jun. The Latest Global Burden of Liver Cancer: A Past and Present Threat. Clinical and molecular hepatology 2023, 29 (2), 355–357. https://doi.org/10.3350/cmh.2023.0070.

Addissouky, T. A.; Wang, Y.; Fayed; El, E.; Ibrahim; Abdel Moneim El‐Torgoman. Novel Biomarkers Assist in Detection of Liver Fibrosis in HCV Patients. Egyptian Liver Journal 2021, 11 (1). https://doi.org/10.1186/s43066-021-00156-x.

Laface, C.; Ranieri, G.; Felicia Maria Maselli; Ambrogio, F.; Foti, C.; Ammendola, M.; Laterza, M.; Cazzato, G.; Riccardo Memeo; Mastrandrea, G.; Lioce, M.; Fedele, P. Immunotherapy and the Combination with Targeted Therapies for Advanced Hepatocellular Carcinoma. Cancers 2023, 15 (3), 654–654. https://doi.org/10.3390/cancers15030654.

Trivella, J.; John, B.; Levy, C. Primary Biliary Cholangitis: Epidemiology, Prognosis, and Treatment. Hepatology communications 2023, 7 (6). https://doi.org/10.1097/hc9.0000000000000179.

Paloma Sangro; Manuel; Sangro, B.; D’Avola, D. Metabolic Dysfunction–Associated Fatty Liver Disease (MAFLD): An Update of the Recent Advances in Pharmacological Treatment. Journal of Physiology and Biochemistry 2023. https://doi.org/10.1007/s13105-023-00954-4.

Braude, M.; Roberts, S. K.; Majeed, A.; Lubel, J. S.; Jirayut Prompen; Dev, A.; Sievert, W.; Bloom, S.; Gow, P. J.; Kemp, W. Liver Stiffness (Fibroscan®) Is a Predictor of All‐Cause Mortality in People with Non‐Alcoholic Fatty Liver Disease. Liver International 2022, 43 (1), 90–99. https://doi.org/10.1111/liv.15415.

Ouyang, J.; Yang, Y.; Zhou, Y.; Ye, F.; Wang, Z.; Li, Q.; Xu, Y.; Li Xia Lu; Zhao, X.; Wen, Z.; Zhou, A.; Huang, Z.; Wang, Y.; Cai, J.; Zhao, H.; Zhou, J. The MAPS-CRAFITY Score: A Novel Efficacy Predictive Tool for Unresectable Hepatocellular Carcinoma Treated with Targeted Therapy plus Immunotherapy. Hepatology International 2023. https://doi.org/10.1007/s12072-023-10580-3.

Yang, M.; Pan, Y.; Wang, W. Prognostic Significance of the CRAFITY Score in Hepatocellular Carcinoma Treated with Immunotherapy: A Systematic Review and Meta-Analysis. BMC Cancer 2023, 23 (1). https://doi.org/10.1186/s12885-023-10686-9.

Nevola, R.; Augusto Delle Femine; Rosato, V.; Kondili, L. A.; Maria Rosaria Alfano; Mastrocinque, D.; Imbriani, S.; Perillo, P.; Beccia, D.; Villani, A.; Ruocco, R.; Criscuolo, L.; Montagna, M.; Russo, A.; Marrone, A.; Ferdinando Carlo Sasso; Raffaele Marfella; Rinaldi, L.; Esposito, N.; Barberis, G. Neoadjuvant and Adjuvant Systemic Therapies in Loco-Regional Treatments for Hepatocellular Carcinoma: Are We at the Dawn of a New Era? Cancers 2023, 15 (11), 2950–2950. https://doi.org/10.3390/cancers15112950.

Evanthia Tourkochristou; Assimakopoulos, S. F.; Thomopoulos, K.; Marangos, M.; Triantos, C. NAFLD and HBV Interplay - Related Mechanisms Underlying Liver Disease Progression. Frontiers in Immunology 2022, 13. https://doi.org/10.3389/fimmu.2022.965548.

Li, Y.; Li, Z.; Chen, R.; Lian, M.; Wang, H.; Wei, Y.; You, Z.; Zhang, J.; Li, B.; Li, Y.; Huang, B.; Chen, Y.; Liu, Q.; Lyu, Z.; Liang, X.; Miao, Q.; Xiao, X.; Wang, Q.; Fang, J.; Shi, Y. A Regulatory Variant at 19p13.3 Is Associated with Primary Biliary Cholangitis Risk and ARID3A Expression. Nature Communications 2023, 14 (1). https://doi.org/10.1038/s41467-023-37213-5.

Jelena Jadzic; Danijela Djonic. Bone Loss in Chronic Liver Diseases: Could Healthy Liver Be a Requirement for Good Bone Health? World Journal of Gastroenterology 2023, 29 (5), 825–833. https://doi.org/10.3748/wjg.v29.i5.825.

Airola, C.; Pallozzi, M.; Cerrito, L.; Santopaolo, F.; Stella, L.; Gasbarrini, A.; Francesca Romana Ponziani. Microvascular Thrombosis and Liver Fibrosis Progression: Mechanisms and Clinical Applications. Cells 2023, 12 (13), 1712–1712. https://doi.org/10.3390/cells12131712.

Prakash, S.; Bies, J.; Hassan, M.; Mares, A.; S. Claudia Didia. Portal Vein Thrombosis in Cirrhosis: A Literature Review. Frontiers in Medicine 2023, 10. https://doi.org/10.3389/fmed.2023.1134801.

Krishna, P.; Ashwin Rammohan; Rajesh Rajalingam; Narasimhan, G.; Ramkiran Cherukuru; Deepti Sachan; Akila Rajakumar; Ilankumaran Kaliamoorthy; Mettu Srinivas Reddy; Rela, M. Propensity Score Matched Analysis and Risk Stratification of Donors with G6PD Deficiency in Living Donor Liver Transplantation. Hepatology International 2023. https://doi.org/10.1007/s12072-023-10583-0.

Zeng, K.; Bao, W.-Y.-G.; Wang, Y.; Lu, M.; Yang, J.; Huang, J.; Lu, Q. Non-Invasive Evaluation of Liver Steatosis with Imaging Modalities: New Techniques and Applications. World Journal of Gastroenterology 2023, 29 (17), 2534–2550. https://doi.org/10.3748/wjg.v29.i17.2534.

Asombang, A. W.; Chishinga, N.; Mohamed, M.; Alick Nkhoma; Chipaila, J.; Bright Nsokolo; Manda-Mapalo, M.; Joao; Banda, L.; Dua, K. S. Systematic Review of Cholangiocarcinoma in Africa: Epidemiology, Management, and Clinical Outcomes. BMC Gastroenterology 2023, 23 (1). https://doi.org/10.1186/s12876-023-02687-6.

Khalil, A.; Quaglia, A.; Gélat, P.; Nader Saffari; Rashidi, H.; Davidson, B. R. New Developments and Challenges in Liver Transplantation. Journal of Clinical Medicine 2023, 12 (17), 5586–5586. https://doi.org/10.3390/jcm12175586.

Wang, Z.; Jin, R.; Mei, H.; Xie, Y.; Liu, Z.; Wang, X.; Feng, B. Treatment of Ursodeoxycholic Acid with Glucocorticoids and Immunosuppressants May Improve the Long-Term Survival Rate in Primary Biliary Cholangitis Patients. Medicine 2022, 101 (46), e31395–e31395. https://doi.org/10.1097/md.0000000000031395.

Sohal, A.; Kowdley, K. V. Primary Biliary Cholangitis: Promising Emerging Innovative Therapies and Their Impact on GLOBE Scores. Hepatic Medicine : Evidence and Research 2023, Volume 15, 63–77. https://doi.org/10.2147/hmer.s361077.

Moon, A. M.; Kim, H. P.; Singal, A. G.; Owen, D.; Mishal Mendiratta-Lala; Parikh, N. D.; Rose, S. C.; McGinty, K.; Agala, C. B.; Burke, L. M.; Abate, A.; Ersan Altun; Beyer, C.; Do, J.; Folkert, M. R.; Forbes, C. D.; Hattangadi-Gluth, J. A.; Hayashi, P. H.; Jones, K.; Khatri, G. Thermal Ablation Compared to Stereotactic Body Radiation Therapy for Hepatocellular Carcinoma: A Multicenter Retrospective Comparative Study. Hepatology communications 2023, 7 (7). https://doi.org/10.1097/hc9.0000000000000184.

Chami, P.; Jarnagin, W. R.; Abou-Alfa, G. K.; Harding, J. J.; Kim, N.; Lin, H.; Maria El Homsi; Crane, C. H.; Hajj, C. Non-Surgical Locoregional Therapies Alone or in Combination with Systemic Therapy in Patients with Hepatocellular Carcinoma. Cancers 2023, 15 (6), 1748–1748. https://doi.org/10.3390/cancers15061748.

Heba Mamdouh Farghaly; Shams, M. Y.; Tarek Abd El-Hafeez. Hepatitis c Virus Prediction Based on Machine Learning Framework: A Real-World Case Study in Egypt. Knowledge and Information Systems 2023, 65 (6), 2595–2617. https://doi.org/10.1007/s10115-023-01851-4.


Full Text: PDF

Article Metrics

Abstract View : 225 times
PDF Download : 125 times

DOI: 10.24871/251202453-62

Refbacks

  • There are currently no refbacks.