The Future of Acid Inhibition

Authors

  • Guido NJ Tytgat

DOI:

https://doi.org/10.24871/1232011168-170

Abstract

There are many unmet needs with current gastric acid suppression with proton pump inhibitors (PPIs). Recommended prescription of one standard morning dose for all patients and for all medical conditions must be scientifically inappropriate and far from individualized personal medicine. For several diseases, especially gastroesophageal reflux disease and Barrett esophagus, more intense, more prolonged diurnal acid suppression is indicated. Especially inhibition of nocturnal acid secretion with our current delayed-release PPIs turns out to be difficult. This overview summarizes the actual attempts to improve the control of acid secretion, which is necessary to adapt the degree of acid inhibition to the individual patient needs. To be discussed are: immediately release PPIs, extended PPI formulations, PPIs with a much longer half-life, potassium competitive acid blockers, gastrin antagonists, etc. Future studies have to proof that those novel drug approaches indeed contribute to reduce the unmet needs.
Keywords: acid secretion, PPI, nocturnal acid secretion
VOLUME 12, NUMBER 3, December 2011

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Published

2011-01-12

How to Cite

Tytgat, G. N. (2011). The Future of Acid Inhibition. The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy, 12(3), 168–170. https://doi.org/10.24871/1232011168-170

Issue

VOLUME 12, NUMBER 3, December 2011

Section

Review Article

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