The Role of Fecal M2-Pyruvate Kinase (M2-PK) in Colorectal Cancer Screening

Authors

  • Nur Chandra Bunawan Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia/Dr. Cipto Mangunkusumo General National Hospital, Jakarta
  • Marcellus Simadibrata Division of Gastroenterology, Department of Internal Medicine, Universitas Indonesia/Dr. Cipto Mangunkusumo General National Hospital, Jakarta

DOI:

https://doi.org/10.24871/181201738-42

Keywords:

M2-pyruvate kinase, M2-PK, fecal, colorectal cancer, screening

Abstract

Colorectal cancer is a malignancy with high incidence and mortality rate. The long carsinogenesis sequence from adenoma unto carsinoma enable early detection and screening as part of the management but until recently the commercialy available test has low sensitivity and specificity. M2-pyruvate kinase (M2-PK), an isomer of glycolisis enzyme involved in aerobic metabolism, is found in high amount in cancerous cell and is shed unto luminal mucosa in colorectal cancer. Quantification of this protein in feces is a promising method to detect malignant lesion of colon. Several studies until recently demonstrate moderate sensitivity and specificity but clearly with better performance than commonly-used gFOBT.

Downloads

Published

2017-07-14

How to Cite

Bunawan, N. C., & Simadibrata, M. (2017). The Role of Fecal M2-Pyruvate Kinase (M2-PK) in Colorectal Cancer Screening. The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy, 18(1), 38–42. https://doi.org/10.24871/181201738-42

Issue

Vol. 18 No. 1 (2017): VOLUME 18, NUMBER 1, April 2017

Section

Review Article

License

Authors who publish with this journal agree to the following terms:

a. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.

b. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.

c. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).