Correlation Between Fibrosis-4 (FIB-4) Score and Metavir Score of Chronic Hepatitis C (CHC) Patients in Saiful Anwar Hospital Malang

Authors

  • Ekamaya Sofa Irawati Department of Internal Medicine, Faculty of Medicine, Universitas Brawijaya, Malang
  • Bogi Pratomo Division of Gastroentero-hepatology, Department of Internal Medicine, Faculty of Medicine, Universitas Brawijaya/Dr. Saiful Anwar General Hospital, Malang

DOI:

https://doi.org/10.24871/201201923-26

Keywords:

Fibrosis-4 (FIB-4), Metavir, chronic hepatitis C, fibrosis

Abstract

Background: Hepatitis C still remain a serious problem in Indonesia lead to increasing prevalence , major morbidity and mortality. Liver biopsy is gold standar, invasive procedure for liver fibrosis staging for treatment monitoring and fibrosis regression. Fibrosis-4 (FIB-4) score has been proposed as a non-invasive, easy, inexpensive as alternative indirect marker for the assessment of liver fibrosis in chronic hepatitis C (CHC).

Method: Analytical cross sectional study was conducted among 54 patients with CHC from 2012 -2017 in Saiful Anwar Hospital Malang. Subjects were examined for complete blood count, aspartate aminotransferase (AST), alanine aminotransferase (ALT), anti hepatitis C virus (anti HCV), hepatitis C virus ribonucleic acid (HCV RNA), genotype, and performed liver biopsy. Statistical analysis was performed using Spearman test and statistical significant was assumed when p < 0,05.

Results: Fifty four (54) patients were fulfilled the selection criteria from total 67 patients. 29 (53%) males, and 25 (47%) were females. The characteristic were 33 (61%) genotype 1, 12 (22%) genotype 2, 5 (9%) genotype 3, and undetermined 3 (6%); with means of  HCV RNA titer 2,57 x 106, AST 79 ± 44 IU/L, ALT 77 ± 48 IU/L platelet 160.000/mm3. Distribution of Metavir F1 10 (19%) ,  Metavir F2 31(57%), Metavir F3  6(11%), and Metavir F4 7 (13%). Median of FIB-4 score as Metavir F1 1,88;Metavir F2 3,24; Metavir F3 5,36; Metavir F4 4,36. There was positive correlation between FIB-4 score and Metavir score (r = 0.38; p = 0,01).

Conclusion: This study indicate that there was significant correlation between FIB-4 score and Metavir score in CHC patients.

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Published

2020-07-22

How to Cite

Irawati, E. S., & Pratomo, B. (2020). Correlation Between Fibrosis-4 (FIB-4) Score and Metavir Score of Chronic Hepatitis C (CHC) Patients in Saiful Anwar Hospital Malang. The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy, 20(1), 23–26. https://doi.org/10.24871/201201923-26

Issue

Vol. 20 No. 1 (2019): VOLUME 20, NUMBER 1, April 2019

Section

Original Articles

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