The Effect of Perioperative Probiotics or Synbiotics on Postoperative Ileus in Patients Undergoing Abdominal Surgery: An Evidence-based Case Report
DOI:
https://doi.org/10.24871/251202476-82Keywords:
probiotics, synbiotics, postoperative ileus, abdominal surgeryAbstract
Aims: To explore the effects of perioperative probiotics or synbiotics supplementation on postoperative in patients undergoing abdominal surgery.
Method: A literature search was conducted on four databases, PubMed, Cochrane, ProQuest, and Scopus, by using MeSH Term. The article selection process was undertaken by screening the titles or abstracts, reviewing the full texts, and determining their compliance with the inclusion and exclusion criteria. Two systematic review/meta-analysis of randomized controlled trial were critically appraised for validity, importance, and applicability.
Results: Perioperative probiotics or synbiotics supplementation may contribute to gastrointestinal function recovery, including reducing postoperative ileus in gastrointestinal cancer. Supplementation of probiotics or synbiotics reduced overall postoperative complications in patients undergoing colorectal cancer surgery and did not cause any side effects. However, the administration of probiotics or synbiotics was not associated with the incidence of postoperative ileus.
Conclusion: Perioperative probiotics or synbiotics supplementation can be considered in promoting postoperative gastrointestinal function in abdominal surgery. However, their effect on reducing the incidence of postoperative ileus is still inconsistent.
References
Dobson GP. Trauma of major surgery: A global problem that is not going away. Int J Surg. 2020;81:47–54.
Wolthuis AM, Bislenghi G, Fieuws S, de Buck van Overstraeten A, Boeckxstaens G, D’Hoore A. Incidence of prolonged postoperative ileus after colorectal surgery: A systematic review and meta‐analysis. Colorectal Dis. 2016;18:O1-9.
Traeger L, Koullouros M, Bedrikovetski S, Kroon HM, Thomas ML, Moore JW, et al. Cost of postoperative ileus following colorectal surgery: A cost analysis in the Australian public hospital setting. Colorectal Dis. 2022;24:1416–26.
Venara A, Neunlist M, Slim K, Barbieux J, Colas PA, Hamy A, et al. Postoperative ileus: Pathophysiology, incidence, and prevention. J Visc Surg. 2016;153:439–46.
Alhashemi M, Fiore JF, Safa N, Al Mahroos M, Mata J, Pecorelli N, et al. Incidence and predictors of prolonged postoperative ileus after colorectal surgery in the context of an enhanced recovery pathway. Surg Endosc. 2019;33:2313–22..
Folwarski M, Dobosz M, Małgorzewicz S, Skonieczna-Zydecka K, Kazmierczak-Siedlecka K. Effects of Lactobacillus rhamnosus GG on early postoperative outcome after pylorus-preserving pancreatoduodenectomy: A randomized trial. Eur Rev Med Pharmacol Sci. 2021;25:397–405.
Gibiino G, Binda C, Cristofaro L, Sbrancia M, Coluccio C, Petraroli C, et al. Dysbiosis and gastrointestinal surgery: Current insights and future research. Biomedicines. 2022;10:2532.
Sanders ME, Merenstein DJ, Reid G, Gibson GR, Rastall RA. Probiotics and prebiotics in intestinal health and disease: From biology to the clinic. Nat Rev Gastroenterol Hepatol. 2019;16:605–16.
Swanson KS, Gibson GR, Hutkins R, Reimer RA, Reid G, Verbeke K, et al. The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of synbiotics. Nat Rev Gastroenterol Hepatol. 2020;17:687–701.
Tang G, Huang W, Tao J, Wei Z. Prophylactic effects of probiotics or synbiotics on postoperative ileus after gastrointestinal cancer surgery: A meta-analysis of randomized controlled trials. PLoS One. 2022;17:1–15.
An S, Kim K, Kim MH, Jung JH, Kim Y. Perioperative probiotics application for preventing postoperative complications in patients with colorectal cancer: A systematic review and meta-analysis. Medicina. 2022;58:1644.
Bajramagic S, Hodzic E, Mulabdic A, Holjan S, Smajlovic SV, Rovcanin A. Usage of probiotics and its clinical significance at surgically treated patients suffering from colorectal carcinoma. Med Arch. 2019;73:316–20.
Chowdhury AH, Adiamah A, Kushairi A, Varadhan KK, Krznaric Z, Kulkarni AD, et al. Perioperative probiotics or synbiotics in adults undergoing elective abdominal surgery: A systematic review and meta-analysis of randomized controlled trials. Ann Surg. 2020;271:1036–47.
Rodríguez-Padilla Á, Morales-Martín G, Pérez-Quintero R, Gómez-Salgado J, Balongo-García R, Ruiz-Frutos C. Postoperative ileus after stimulation with probiotics before ileostomy closure. Nutrients. 2021;13:1–10.
Kotzampassi K, Stavrou G, Damoraki G, Georgitsi M, Basdanis G, Tsaousi G, et al. A four-probiotics regimen reduces postoperative complications after colorectal surgery: A randomized, double-blind, placebo-controlled study. World J Surg. 2015;39:2776–83.
Xu R, Ding Z, Zhao P, Tang L, Tang X, Xiao S. The effects of early post-operative soluble dietary fiber enteral nutrition for colon cancer. Nutrients. 2016;8:584.
Yang Y, Xia Y, Chen H, Hong L, Feng J, Yang J, et al. The effect of perioperative probiotics treatment for colorectal cancer: Short-term outcomes of a randomized controlled trial. Oncotarget. 2016:7:8432-
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