Prevalence and Association of Helicobacter pylori Infection in Gastric Disease at Dr. Cipto Mangunkusumo General National Hospital 2010–2021
), Dewi Mustikarani(2),
(1) Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia/Dr. Cipto Mangunkusumo General National Hospital, Jakrta
(2) Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia/Dr. Cipto Mangunkusumo General National Hospital, Jakarta
Corresponding Author
Abstract
Background: Several studies showed contrasting associations between Helicobacter pylori infection and organic gastric disorders. We aim to determine the association between H. pylori infection and gastroesophageal reflux disease (GERD), gastric polyp, and gastric cancer in an Indonesian national referral hospital.
Method: Data collected from patients referred to Cipto Mangunkusumo General National Hospital, Jakarta, Indonesia, from 2010 to 2021, with complete H. pylori test and endoscopy from electronic medical record. Chi-square analysis and logistic regression were performed to determine the association with a significant p-value of < 0.05.
Results: Three hundred and fourteen consecutive patients were enrolled, with a median age of 51.0 (16‒85), and 131 (41.7%) of them were males. The prevalence of H. pylori infection in organic gastric disease was 7.6% (n = 24) with 0.3% (n = 1) of them has gastric cancer, 3.2% gastric polyp (n = 10), and 4.1% (n = 13) GERD. A proven association between H. pylori infection and GERD was observed (RR = 26.42; 95% CI: 76.12‒114.05; p = 0.000) and esophagitis (RR = 2.44; 95% CI: 1.71‒3.49; p = 0.000). However, no significant association was found between H. pylori infection and gastric cancer (RR = 4.07; 95% CI: 0.26‒64.09; p = 0.28), and gastric polyp (RR = 1.16; 95% CI: 0.61‒2.22; p = 0.65).
Conclusion: Our study suggested association of H. pylori infection in GERD and oesophagitis patients. Insignificant association was observed between H. pylori infection and gastric cancer, and gastric polyp.
Keywords: Helicobacter pylori, esophagitis, GERD, gastric polyps, gastric cancer
References
Thorell K, Lehours P, Vale FF. Genomics of Helicobacter
pylori. Helicobacter. 2017 Sep;22 Suppl 1.
Scida S, Russo M, Miraglia C, Leandro G, Franzoni L, Meschi
T, et al. Relationship between helicobacter pylori infection
and GERD. Acta Biomed. 2018;89(4):40–3.
Santos MLC, De Brito BB, Da Silva FAF, Sampaio MM,
Marques HS, Oliveira E Silva N, et al. Helicobacter
pylori infection: Beyond gastric manifestations. World J
Gastroenterol. 2020;26(28):4076–93.
Ahn HJ, Lee DS. Helicobacter pylori in gastric carcinogenesis.
World J Gastrointest Oncol. 2015;7(12):455–65.
Miftahussurur M, Syam AF, Nusi IA, Makmun D, Waskito
LA, Zein LH, et al. Surveillance of Helicobacter pylori
antibiotic susceptibility in Indonesia: Different resistance types
among regions and with novel genetic mutations. PLoS One.
;11(12):1–17.
Hang DV, Minh DT, Hoc TH, Phuoc LH, Son TQ, Le NT.
H. pylori Infection and Colorectal Cancers by Anatomical
Locations. Asian Pac J Cancer Prev. 2020 Aug;21(8):2431–7.
Aftab H, Miftahussurur M, Subsomwong P, Ahmed F, Khan
AKA, Matsumoto T, et al. Two populations of less-virulent
Helicobacter pylori genotypes in Bangladesh. PLoS One.
;12(8):e0182947.
Goto Y, Syam AF, Darnindro N, Hapsari FCP. Prevalence and
Risk Factors for Helicobacter Pylori Infection among Healthy
Inhabitants in Northern Jakarta, Indonesia. Asian Pac J Cancer
Prev. 2016 Oct;17(10):4747–53.
Syam AF, Miftahussurur M, Makmun D, Nusi IA, Zain LH,
Zulkhairi, et al. Risk Factors and Prevalence of Helicobacter
pylori in Five Largest Islands of Indonesia: A Preliminary
Study. PLoS One. 2015;10(11):e0140186.
El-Serag HB, Sweet S, Winchester CC, Dent J. Update on
the epidemiology of gastro-oesophageal reflux disease: a
systematic review. Gut. 2014 Jun;63(6):871–80.
Clarrett DM, Hachem C. Gastroesophageal Reflux Disease
(GERD). Mo Med. 2018;115(3):214–8.
Katz PO, Gerson LB, Vela MF. Guidelines for the diagnosis
and management of gastroesophageal reflux disease. Am J
Gastroenterol. 2013 Mar;108(3):308–28; quiz 329.
Xue Y, Zhou LY, Lin SR, Hou XH, Li ZS, Chen MH, et al.
Effect of Helicobacter pylori eradication on reflux esophagitis
therapy: A multi-center randomized control study. Chin Med
J (Engl). 2015;128(8):995–9.
Polat FR, Polat S. The effect of Helicobacter pylori on
gastroesophageal reflux disease. JSLS J Soc Laparoendosc
Surg. 2012;16(2):260–3.
Jie W, Qinghong X, Zhitao C. Association of Helicobacter
pylori infection with gastroesophageal reflux disease. J Int
Med Res. 2019 Feb;47(2):748–53.
Niknam R, Lankarani KB, Moghadami M, Taghavi SA, Zahiri
L, Fallahi MJ. The association between helicobacter pylori
infection and erosive gastroesophageal reflux disease; a crosssectional
study. BMC Infect Dis [Internet]. 2022;22(1):1–11.
Available from: https://doi.org/10.1186/s12879-022-07278-6
Grande M, Lisi G, De Sanctis F, Grande S, Esser A,
Campanelli M, et al. Does a relationship still exist between
gastroesophageal reflux and Helicobacter pylori in patients
with reflux symptoms? World J Surg Oncol. 2014;12(1):4–9.
Li Z, Wu C, Li L, Wang Z, Xie H, He X, et al. Effect of longterm
proton pump inhibitor administration on gastric mucosal
atrophy: A meta-analysis. Saudi J Gastroenterol Off J Saudi
Gastroenterol Assoc. 2017;23(4):222–8.
Dacha S, Razvi M, Massaad J, Cai Q, Wehbi M.
Hypergastrinemia. Gastroenterol Rep. 2015 Aug;3(3):201–8.
Sayehmiri K, Abangah G, Kalvandi G, Tavan H, Aazami S.
Prevalence of peptic ulcer in Iran: Systematic review and
meta-analysis methods. J Res Med Sci. 2018;23:8.
Keikha M, Ali-Hassanzadeh M, Karbalaei M, Karbalaei M.
Association of Helicobacter pylori vacA genotypes and peptic
ulcer in Iranian population: A systematic review and metaanalysis.
BMC Gastroenterol. 2020;20(1):1–11.
Zamani M, Ebrahimtabar F, Zamani V, Miller WH, Alizadeh-
Navaei R, Shokri-Shirvani J, et al. Systematic review with
meta-analysis: the worldwide prevalence of Helicobacter
pylori infection. Aliment Pharmacol & Ther [Internet].
;47(7):868–76. Available from: https://onlinelibrary.
wiley.com/doi/abs/10.1111/apt.14561
Goudoever V. Hiatal Hernia : A Cause of Esophageal Reflux
Disease. 2023;11(1000313):10–1.
Butt J, Varga MG, Wang T, Tsugane S, Shimazu T, Zheng
W, et al. Smoking, Helicobacter Pylori Serology, and Gastric
Cancer Risk in Prospective Studies from China, Japan, and
Korea. Cancer Prev Res (Phila). 2019 Oct;12(10):667–74.
Brim H, Zahaf M, Laiyemo AO, Nouraie M, Pérez-Pérez
GI, Smoot DT, et al. Gastric Helicobacter pylori infection
associates with an increased risk of colorectal polyps in
African Americans. BMC Cancer. 2014 Apr;14:296.
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