Prevalence and Association of Helicobacter pylori Infection in Gastric Disease at Dr. Cipto Mangunkusumo General National Hospital 2010–2021

Marcellus Simadibrata(1), Dewi Mustikarani(2),

(1) Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia/Dr. Cipto Mangunkusumo General National Hospital, Jakrta
(2) Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia/Dr. Cipto Mangunkusumo General National Hospital, Jakarta
Corresponding Author


Background: Several studies showed contrasting associations between Helicobacter pylori infection and organic gastric disorders. We aim to determine the association between H. pylori infection and gastroesophageal reflux disease (GERD), gastric polyp, and gastric cancer in an Indonesian national referral hospital.

Method: Data collected from patients referred to Cipto Mangunkusumo General National Hospital, Jakarta, Indonesia, from 2010 to 2021, with complete H. pylori test and endoscopy from electronic medical record. Chi-square analysis and logistic regression were performed to determine the association with a significant p-value of < 0.05.

Results: Three hundred and fourteen consecutive patients were enrolled, with a median age of 51.0 (16‒85), and 131 (41.7%) of them were males. The prevalence of H. pylori infection in organic gastric disease was 7.6% (n = 24) with 0.3% (n = 1) of them has gastric cancer, 3.2% gastric polyp (n = 10), and 4.1% (n = 13) GERD. A proven association between H. pylori infection and GERD was observed (RR = 26.42; 95% CI: 76.12‒114.05; p = 0.000) and esophagitis (RR = 2.44; 95% CI: 1.71‒3.49; p = 0.000). However, no significant association was found between H. pylori infection and gastric cancer (RR = 4.07; 95% CI: 0.26‒64.09; p = 0.28), and gastric polyp (RR = 1.16; 95% CI: 0.61‒2.22; p = 0.65).

Conclusion: Our study suggested association of H. pylori infection in GERD and oesophagitis patients. Insignificant association was observed between H. pylori infection and gastric cancer, and gastric polyp.

Keywords: Helicobacter pylori, esophagitis, GERD, gastric polyps, gastric cancer


Thorell K, Lehours P, Vale FF. Genomics of Helicobacter

pylori. Helicobacter. 2017 Sep;22 Suppl 1.

Scida S, Russo M, Miraglia C, Leandro G, Franzoni L, Meschi

T, et al. Relationship between helicobacter pylori infection

and GERD. Acta Biomed. 2018;89(4):40–3.

Santos MLC, De Brito BB, Da Silva FAF, Sampaio MM,

Marques HS, Oliveira E Silva N, et al. Helicobacter

pylori infection: Beyond gastric manifestations. World J

Gastroenterol. 2020;26(28):4076–93.

Ahn HJ, Lee DS. Helicobacter pylori in gastric carcinogenesis.

World J Gastrointest Oncol. 2015;7(12):455–65.

Miftahussurur M, Syam AF, Nusi IA, Makmun D, Waskito

LA, Zein LH, et al. Surveillance of Helicobacter pylori

antibiotic susceptibility in Indonesia: Different resistance types

among regions and with novel genetic mutations. PLoS One.


Hang DV, Minh DT, Hoc TH, Phuoc LH, Son TQ, Le NT.

H. pylori Infection and Colorectal Cancers by Anatomical

Locations. Asian Pac J Cancer Prev. 2020 Aug;21(8):2431–7.

Aftab H, Miftahussurur M, Subsomwong P, Ahmed F, Khan

AKA, Matsumoto T, et al. Two populations of less-virulent

Helicobacter pylori genotypes in Bangladesh. PLoS One.


Goto Y, Syam AF, Darnindro N, Hapsari FCP. Prevalence and

Risk Factors for Helicobacter Pylori Infection among Healthy

Inhabitants in Northern Jakarta, Indonesia. Asian Pac J Cancer

Prev. 2016 Oct;17(10):4747–53.

Syam AF, Miftahussurur M, Makmun D, Nusi IA, Zain LH,

Zulkhairi, et al. Risk Factors and Prevalence of Helicobacter

pylori in Five Largest Islands of Indonesia: A Preliminary

Study. PLoS One. 2015;10(11):e0140186.

El-Serag HB, Sweet S, Winchester CC, Dent J. Update on

the epidemiology of gastro-oesophageal reflux disease: a

systematic review. Gut. 2014 Jun;63(6):871–80.

Clarrett DM, Hachem C. Gastroesophageal Reflux Disease

(GERD). Mo Med. 2018;115(3):214–8.

Katz PO, Gerson LB, Vela MF. Guidelines for the diagnosis

and management of gastroesophageal reflux disease. Am J

Gastroenterol. 2013 Mar;108(3):308–28; quiz 329.

Xue Y, Zhou LY, Lin SR, Hou XH, Li ZS, Chen MH, et al.

Effect of Helicobacter pylori eradication on reflux esophagitis

therapy: A multi-center randomized control study. Chin Med

J (Engl). 2015;128(8):995–9.

Polat FR, Polat S. The effect of Helicobacter pylori on

gastroesophageal reflux disease. JSLS J Soc Laparoendosc

Surg. 2012;16(2):260–3.

Jie W, Qinghong X, Zhitao C. Association of Helicobacter

pylori infection with gastroesophageal reflux disease. J Int

Med Res. 2019 Feb;47(2):748–53.

Niknam R, Lankarani KB, Moghadami M, Taghavi SA, Zahiri

L, Fallahi MJ. The association between helicobacter pylori

infection and erosive gastroesophageal reflux disease; a crosssectional

study. BMC Infect Dis [Internet]. 2022;22(1):1–11.

Available from:

Grande M, Lisi G, De Sanctis F, Grande S, Esser A,

Campanelli M, et al. Does a relationship still exist between

gastroesophageal reflux and Helicobacter pylori in patients

with reflux symptoms? World J Surg Oncol. 2014;12(1):4–9.

Li Z, Wu C, Li L, Wang Z, Xie H, He X, et al. Effect of longterm

proton pump inhibitor administration on gastric mucosal

atrophy: A meta-analysis. Saudi J Gastroenterol Off J Saudi

Gastroenterol Assoc. 2017;23(4):222–8.

Dacha S, Razvi M, Massaad J, Cai Q, Wehbi M.

Hypergastrinemia. Gastroenterol Rep. 2015 Aug;3(3):201–8.

Sayehmiri K, Abangah G, Kalvandi G, Tavan H, Aazami S.

Prevalence of peptic ulcer in Iran: Systematic review and

meta-analysis methods. J Res Med Sci. 2018;23:8.

Keikha M, Ali-Hassanzadeh M, Karbalaei M, Karbalaei M.

Association of Helicobacter pylori vacA genotypes and peptic

ulcer in Iranian population: A systematic review and metaanalysis.

BMC Gastroenterol. 2020;20(1):1–11.

Zamani M, Ebrahimtabar F, Zamani V, Miller WH, Alizadeh-

Navaei R, Shokri-Shirvani J, et al. Systematic review with

meta-analysis: the worldwide prevalence of Helicobacter

pylori infection. Aliment Pharmacol & Ther [Internet].

;47(7):868–76. Available from: https://onlinelibrary.

Goudoever V. Hiatal Hernia : A Cause of Esophageal Reflux

Disease. 2023;11(1000313):10–1.

Butt J, Varga MG, Wang T, Tsugane S, Shimazu T, Zheng

W, et al. Smoking, Helicobacter Pylori Serology, and Gastric

Cancer Risk in Prospective Studies from China, Japan, and

Korea. Cancer Prev Res (Phila). 2019 Oct;12(10):667–74.

Brim H, Zahaf M, Laiyemo AO, Nouraie M, Pérez-Pérez

GI, Smoot DT, et al. Gastric Helicobacter pylori infection

associates with an increased risk of colorectal polyps in

African Americans. BMC Cancer. 2014 Apr;14:296.

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DOI: 10.24871/2432023216


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